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Proceedings Paper

Propagation characteristics of autofluorescence in tissue
Author(s): Hongbo Xie; Xiaodong Chen; Zhi Xu; Daoyin Yu
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Paper Abstract

This paper studied the LIAF transportation mechanism in tissue by a series of Monte-Carlo simulations, and investigated the effects of boundary condition, optical properties, structure, and the quantum yield of tissue chromophores on LIAF spectra. According to the layered structure of gastrointestinal tract and the penetration depth of laser beam, a bi-layer tissue model was set up for simulating the distribution of LIAF spectra obtained from normal tissue and adenoma. The results showed that an index-mismatched boundary reduced both the amount of excitation and emission that are remitted from the medium surface. In addition, the origin of fluorescence in normal and cancerous tissues was discussed. We found out that the cancerous mucosa has significant lower fluorescence efficiency compared to normal tissues. The reason is two-fold: firstly, the fluorescence quantum efficiency ofcancerous mucosa, which is the percentage of fluorescence of the cancerous tissues that get excited, is lower than that of normal mucosa., secondly, due to the higher absorption coefficient of cancerous mucosa, the amount of excitation light reaching submucosa layer is reduced, resulting in significantly lower remitted fluorescence from submucosa layer.

Paper Details

Date Published: 12 September 2002
PDF: 5 pages
Proc. SPIE 4916, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment, (12 September 2002); doi: 10.1117/12.482976
Show Author Affiliations
Hongbo Xie, Tianjin Univ. (China)
Xiaodong Chen, Tianjin Univ. (China)
Zhi Xu, Tianjin Univ. (China)
Daoyin Yu, Tianjin Univ. (China)

Published in SPIE Proceedings Vol. 4916:
Optics in Health Care and Biomedical Optics: Diagnostics and Treatment
Britton Chance; Mingzhe Chen; Gilwon Yoon, Editor(s)

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