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Proceedings Paper

Endoscopic tissue autofluorescence measurements in the upper aerodigestive tract and the bronchi
Author(s): Daniel Braichotte; Georges A. Wagnieres; Philippe Monnier; Jean-Francois Savary; Roland Bays; Hubert van den Bergh; Andre Chatelain
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Paper Abstract

A single multimode optical fiber is used to excite and collect tissue autofluorescence as well as the fluorescence of an IV-injected fluorescent tumor marker. Measurements of the relative fluorescence intensity of a tumor marker as a function of the time after IV injection permit measurement of the kinetics of this substance in tumor, normal tissue, and skin. The authors believe that these are the first measurements of this kind in patients. Furthermore, the autofluorescence spectrum generated at several excitation wavelengths in different tissues is compared, for instance in the oesophagus, the bronchi, and the tongue. The measuring system is based on an optical multichannel analyzer which measures the fluorescence excited by monochromatic radiation from a spectrally filtered Xe lamp. A correlation between the observed pharmacokinetics and tumor properties like the degree of vascularization is of fundamental importance for each selected tumor marker. Also, the results of these measurements are used for the optical detection of tumors.

Paper Details

Date Published: 1 November 1991
PDF: 7 pages
Proc. SPIE 1525, Future Trends in Biomedical Applications of Lasers, (1 November 1991); doi: 10.1117/12.48222
Show Author Affiliations
Daniel Braichotte, Ecole Polytechnique Federale de Lausanne (Switzerland)
Georges A. Wagnieres, Ecole Polytechnique Federale de Lausanne (Switzerland)
Philippe Monnier, CHUV Hospital (Switzerland)
Jean-Francois Savary, CHUV Hospital (Switzerland)
Roland Bays, Ecole Polytechnique Federale de Lausanne (Switzerland)
Hubert van den Bergh, Ecole Polytechnique Federale de Lausanne (Switzerland)
Andre Chatelain, Ecole Polytechnique Federale de Lausanne (Switzerland)

Published in SPIE Proceedings Vol. 1525:
Future Trends in Biomedical Applications of Lasers
Lars Othar Svaasand, Editor(s)

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