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Proceedings Paper

Phthalocyanines as phototherapeutic agents for tumors
Author(s): Giulio Jori; Elena Reddi; Roberta Biolo; Laura Polo; Giuliana Valduga
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Paper Abstract

Zn(II)-phthalocyanine (ZnPc) is a tetraazaisoindole pigment which can be prepared by chemical synthesis with a high degree of purity, and it efficiently absorbs 680 nm of light. These properties, associated with its ability to generate activated oxygen species (e.g., singlet oxygen) upon photoexcitation, make ZnPc a potential phototherapeutic agent. Actually, upon delivery of ZnPc to tumor-bearing animals after incorporation into liposomal vesicles, the dye was uptaken and retained by the tumor tissue in significant amounts and with a good degree of selectivity. Irradiation of the ZnPc-loaded tumor area with ca. 680 nm of light caused tumor necrosis to an extent which was related to the dye concentration in the tumor.

Paper Details

Date Published: 1 November 1991
PDF: 10 pages
Proc. SPIE 1525, Future Trends in Biomedical Applications of Lasers, (1 November 1991); doi: 10.1117/12.48199
Show Author Affiliations
Giulio Jori, Univ. of Padova (Italy)
Elena Reddi, Univ. of Padova (Italy)
Roberta Biolo, Univ. of Padova (Italy)
Laura Polo, Univ. of Padova (Italy)
Giuliana Valduga, Univ. of Padova (Italy)

Published in SPIE Proceedings Vol. 1525:
Future Trends in Biomedical Applications of Lasers
Lars Othar Svaasand, Editor(s)

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