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Arterial stiffness measurements with acoustic radiation force impulse imaging
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Paper Abstract

We have developed a new method of imaging the mechanical properties of tissues based on very brief (<1msec) and localized applications of acoustic radiation force and the ultrasonic measurement of local tissues' responses to that force. Initial results with this technique demonstrate its ability to image mechanical properties of the medial and adventitial layers within ex vivo and in vivo arteries, and to distinguish hard and soft atherosclerotic plaques from normal vessel wall. We have labeled this method Acoustic Radiation Force Impulse (ARFI) imaging. We describe studies to utilize this technique in the characterization of diffuse and focal atherosclerosis. We describe phantom trials and finite element simulations which explore the fundamental resolution and contrast achievable with this method. We describe in vivo and ex vivo trials in the popliteal, femoral and brachial arteries to assess the relationship between the mechanical properties of healthy and diseased arteries provided by this method and those obtained by alternative methods.

Paper Details

Date Published: 23 May 2003
PDF: 7 pages
Proc. SPIE 5035, Medical Imaging 2003: Ultrasonic Imaging and Signal Processing, (23 May 2003); doi: 10.1117/12.479966
Show Author Affiliations
Gregg E. Trahey, Duke Univ. (United States)
Jeremy J. Dahl, Duke Univ. (United States)
Stephen A. McAleavey, Duke Univ. (United States)
Caterina M. Gallippi, Duke Univ. (United States)
Kathryn R. Nightingale, Duke Univ. (United States)

Published in SPIE Proceedings Vol. 5035:
Medical Imaging 2003: Ultrasonic Imaging and Signal Processing
William F. Walker; Michael F. Insana, Editor(s)

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