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Proceedings Paper

Cardiac elastography: detecting pathological changes in myocardium tissues
Author(s): Elisa E. Konofagou; Timothy Harrigan; Scott Solomon
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Paper Abstract

Estimation of the mechanical properties of the cardiac muscle has been shown to play a crucial role in the detection of cardiovascular disease. Elastography was recently shown feasible on RF cardiac data in vivo. In this paper, the role of elastography in the detection of ischemia/infarct is explored with simulations and in vivo experiments. In finite-element simulations of a portion of the cardiac muscle containing an infarcted region, the cardiac cycle was simulated with successive compressive and tensile strains ranging between -30% and 20%. The incremental elastic modulus was also mapped uisng adaptive methods. We then demonstrated this technique utilizing envelope-detected sonographic data (Hewlett-Packard Sonos 5500) in a patient with a known myocardial infarction. In cine-loop and M-Mode elastograms from both normal and infarcted regions in simulations and experiments, the infarcted region was identifed by the up to one order of magnitude lower incremental axial displacements and strains, and higher modulus. Information on motion, deformation and mechanical property should constitute a unique tool for noninvasive cardiac diagnosis.

Paper Details

Date Published: 23 May 2003
PDF: 10 pages
Proc. SPIE 5035, Medical Imaging 2003: Ultrasonic Imaging and Signal Processing, (23 May 2003); doi: 10.1117/12.479932
Show Author Affiliations
Elisa E. Konofagou, Brigham and Women's Hospital/Harvard Medical School (United States)
Timothy Harrigan, Exponent, Inc. (United States)
Scott Solomon, Brigham and Women's Hospital/Harvard Medical School (United States)

Published in SPIE Proceedings Vol. 5035:
Medical Imaging 2003: Ultrasonic Imaging and Signal Processing
William F. Walker; Michael F. Insana, Editor(s)

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