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Proceedings Paper

Ultrasound elastomicroscopy for articular cartilage: from static to transient and 1D to 2D
Author(s): Yongping Zheng; Sharon Lori Bridal; Jun Shi; Amena Saied; Minghua Lu; Britta Jaffre; Arthur F. T. Mak; Pascal Laugier; Ling Qin
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Paper Abstract

Articular cartilage (AC) is a biological weight-bearing tissue covering the ends of articulating bones within synovial joints. Its function very much depends on the unique multi-layered structure and the depth-dependent material properties, which have not been well invetigated nondestructively. In this study, transient depth-dependent material properties of bovine patella cartilage were measured using ultrasound elastomicroscopy methods. A 50 MHz focused ultrasound transducer was used to collect A-mode ultrasound echoes from the articular cartilage during the compression and subsequent force-relaxation. The transient displacements of the cartilage tissues at different depths were calculated from the ultrasound echoes using a cross-correlation technique. It was observed that the strains in the superficial zone were much larger than those in the middle and deep zones as the equilibrium state was approached. The tissues inside the AC layer continued to move during the force-relaxation phase after the compression was completed. This process has been predicted by a biphasic theory. In this study, it has been verified experimentally. It was also observed that the tissue deformations at different depths of AC were much more evenly distributed before force-relaxation. AC specimens were also investigated using a 2D ultrasound elastomicroscopy system that included a 3D translating system for moving the ultrasound transducer over the specimens. B-mode RF ultrasound signals were collected from the specimens under different loading levels applied with a specially designed compressor. Preliminary results demonstrated that the scanning was repeatable with high correlation of radio frequency signals obtained from the same site during different scans when compression level was unchanged (R2 > 0.97). Strains of the AC specimens were mapped using data collected with this ultrasound elastomicroscope. This system can also be potentially used for the assessment of other biological tissues, bioengineered tissues or biomaterials with fine structures.

Paper Details

Date Published: 23 May 2003
PDF: 13 pages
Proc. SPIE 5035, Medical Imaging 2003: Ultrasonic Imaging and Signal Processing, (23 May 2003); doi: 10.1117/12.479896
Show Author Affiliations
Yongping Zheng, Hong Kong Polytechnic Univ. (China)
Sharon Lori Bridal, Lab. d'Imagerie Parametrique UMR CNRS (France)
Univ. Paris IV (France)
Jun Shi, Hong Kong Polytechnic Univ. (China)
Univ. of Science and Technology of China (China)
Amena Saied, Lab. d'Imagerie Parametrique UMR CNRS (France)
Univ. Paris IV (France)
Minghua Lu, Hong Kong Polytechnic Univ. (China)
Britta Jaffre, Lab. d'Imagerie Parametrique UMR CNRS (France)
Univ. Paris IV (France)
Arthur F. T. Mak, Hong Kong Polytechnic Univ. (China)
Pascal Laugier, Lab. d'Imagerie Parametrique UMR CNRS (France)
Univ. Paris VI (France)
Ling Qin, Chinese Univ. of Hong Kong (China)

Published in SPIE Proceedings Vol. 5035:
Medical Imaging 2003: Ultrasonic Imaging and Signal Processing
William F. Walker; Michael F. Insana, Editor(s)

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