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Proceedings Paper

Feedback control of liver thermotherapy using optical spectroscopy
Author(s): Clay R. Buttemere; Ravi S. Chari; Christopher D. Anderson; Anita Mahadevan-Jansen; Wei-Chiang Lin
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Paper Abstract

Thermotherapies such as radio-frequency ablation achieve necrosis of liver tumors through thermal coagulation and are frequently employed when surgical resection is impossible. Currently, thermotherapy procedures suffer from the lack of an adequate feedback control system, making it difficult to know precisely when to terminate therapy. In vitro and in vivo studies were performed on canine liver tissue to determine the feasibility of using fluorescence and diffuse reflectance spectroscopy to provide an objective endpoint for these procedures. The fluorescence and diffuse reflectance spectra of liver tissue exhibited consistent changes over the coagulation process. In vitro results showed a shift in the primary fluorescence peak from 490 nm in the native state to 510 nm in the fully coagulated state; in addition, a three- to four-fold increase in the absolute intensity of the diffuse reflectance spectra was observed upon complete coagulation. Similar spectral alterations were obtained in vivo. Based on our results, fluorescence and diffuse reflectance spectroscopy provide a direct way to assess the biochemical and structural changes associated with tissue thermal damage; hence, they can be developed into a feedback system for thermotherapies.

Paper Details

Date Published: 22 July 2003
PDF: 12 pages
Proc. SPIE 4958, Advanced Biomedical and Clinical Diagnostic Systems, (22 July 2003); doi: 10.1117/12.479803
Show Author Affiliations
Clay R. Buttemere, Vanderbilt Univ. (United States)
Ravi S. Chari, Vanderbilt Univ. Medical Ctr. (United States)
Christopher D. Anderson, Vanderbilt Univ. Medical Ctr. (United States)
Anita Mahadevan-Jansen, Vanderbilt Univ. (United States)
Wei-Chiang Lin, Vanderbilt Univ. (United States)

Published in SPIE Proceedings Vol. 4958:
Advanced Biomedical and Clinical Diagnostic Systems
Tuan Vo-Dinh; Warren S. Grundfest M.D.; David A. Benaron M.D.; Gerald E. Cohn, Editor(s)

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