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Proceedings Paper

Validation of hemoglobin and water molar absorption spectra in near-infrared diffuse optical tomography
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Paper Abstract

Near Infrared diffuse optical tomography was used to measure the molar absorption spectra for de-oxyhemoglobin, oxyhemoglobin and water through phantom experiments. The measured spectra compensate for any systemic errors and errors arising from model-based estimation of concentrations of these chromophores, and show reasonable agreement with existing literature values. The spectra were validated by phantom experiments to obtain the oxygen dissociation curve. Variation of the partial pressure of oxygen in solution yielded results consistent with theory of mean error of 7.6% in estimation of oxygen saturation, and accurate within 5% in estimation of hemoglobin.

Paper Details

Date Published: 29 July 2003
PDF: 9 pages
Proc. SPIE 4955, Optical Tomography and Spectroscopy of Tissue V, (29 July 2003); doi: 10.1117/12.478219
Show Author Affiliations
Subhadra Srinivasan, Dartmouth College (United States)
Brian W. Pogue, Dartmouth College (United States)
Shudong Jiang, Dartmouth College (United States)
Hamid Dehghani, Dartmouth College (United States)
Keith D. Paulsen, Dartmouth College (United States)

Published in SPIE Proceedings Vol. 4955:
Optical Tomography and Spectroscopy of Tissue V
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva M. Sevick-Muraca, Editor(s)

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