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Proceedings Paper

Hybrid DOT and MRI system
Author(s): Gultekin Gulsen; Ozlem Birgul; Orhan Nalcioglu
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Paper Abstract

Recently, there has been a great deal of interest in further improving the in-vivo characterization of tumors by interrogating tissues with multiple simultaneous image based measurement techniques that provide complementary information about the functional state of the tissue under investigation. Besides offering the possibility of complementary information, multi-modality techniques could also be used to improve the measurements done by either modality as well as providing cross validation measurements. Magnetic resonance imaging (MRI) and near-infrared diffuse optical tomography (DOT) are two techniques that, when combined, provide complementary structural and functional information. MRI can be used to obtain detailed structural and metabolic information regarding tumors. On the other hand, DOT can be used to determine local quantitative information regarding tumor composition and metabolism. Thus, a combined system consisting of MRI and DOT has the potential to enhance understanding of the complex biological processes in tumors. In this work, we describe the design of the hybrid DOT-MRI system.

Paper Details

Date Published: 29 July 2003
PDF: 7 pages
Proc. SPIE 4955, Optical Tomography and Spectroscopy of Tissue V, (29 July 2003); doi: 10.1117/12.478189
Show Author Affiliations
Gultekin Gulsen, Univ. of California, Irvine (United States)
Ozlem Birgul, Univ. of California, Irvine (United States)
Orhan Nalcioglu, Univ. of California, Irvine (United States)

Published in SPIE Proceedings Vol. 4955:
Optical Tomography and Spectroscopy of Tissue V
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva M. Sevick-Muraca, Editor(s)

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