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Proceedings Paper

Development of a microfluidic drug delivery neural prosthesis using a wide-bandgap semiconductor waveguide structure
Author(s): Mona R. Safadi; Gregory W. Auner; Raymond Iezzi; Pat McAllister; Gary Abrams
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Paper Abstract

We have developed a microfluidic retinal prosthesis, using wide bandgap optical wavelength semiconductor thin film waveguides, to facilitate spatial and quantitative photactivation of “caged” neurotransmitter to microfluidic channels. Novel waveguide materials and micromachining technology are necessary to fabricate 360 nanometer capable waveguides for the microfluidic device. Single crystal wide bandgap semiconductor thin films are grown on sapphire by plasma source molecular beam epitaxy (PSMBE). 248 nanometer KrF Excimer laser micromachining technology is employed to micro-fabricate wave-guiding channels and microfluidic structures. A waveguide that allows for spatial and temporal drug delivery within the retina was fabricated. In addition, there is a need for a waveguide structure that may be used in physiological drug delivery systems. A device that may deliver ultraviolet light in precise intensities and to selective areas of a microfluidic implant without direct ultraviolet exposure to the biological cells is needed in retinal and cortical implants. Results of a prototype microfluidic waveguide system will be presented.

Paper Details

Date Published: 17 January 2003
PDF: 10 pages
Proc. SPIE 4982, Microfluidics, BioMEMS, and Medical Microsystems, (17 January 2003); doi: 10.1117/12.478158
Show Author Affiliations
Mona R. Safadi, Wayne State Univ. (United States)
Gregory W. Auner, Wayne State Univ. (United States)
Raymond Iezzi, Wayne State Univ. (United States)
Pat McAllister, Wayne State Univ. (United States)
Gary Abrams, Wayne State Univ. (United States)

Published in SPIE Proceedings Vol. 4982:
Microfluidics, BioMEMS, and Medical Microsystems
Holger Becker; Peter Woias, Editor(s)

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