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Proceedings Paper

Eight-channel time-resolved tissue oximeter for functional muscle studies
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Paper Abstract

A portable instrument for tissue oximetry based on time-resolved reflectance spectroscopy was developed. The output pulses of 2 laser diodes (683 and 785 nm, 80 MHz pulse repetition rate, 1 mW average power, 100 ps FWHM) are delayed and coupled into a multimode graded-index fiber (50/125 μm and injected into the tissue. The reflectance photons are collected by 8 independent 1 mm fibers and detected by a 16-anode photomultiplier. A time-correlated single photon counting PC board is used for the parallel acquisition of the curves. Simultaneous estimate of the transport scattering and absorption coefficients is achieved by best fitting of time-resolved reflectance curves with a standard model of Diffusion Theory. The performances of the system were tested on phantoms in terms of stability, reproducibility among channels, and accuracy in the determination of the optical properties. Preliminary in vivo measurements were performed on healthy volunteers to monitor spatial changes in calf (medical and lateral gastrocnemius) oxygen hemoglobin saturation and blood volume during dynamic plantar flexion exercise.

Paper Details

Date Published: 29 July 2003
PDF: 7 pages
Proc. SPIE 4955, Optical Tomography and Spectroscopy of Tissue V, (29 July 2003);
Show Author Affiliations
Rinaldo Cubeddu, INFM and INFN-CNR, Politecnico di Milano (Italy)
Giovanni Biscotti, INFM and INFN-CNR, Politecnico di Milano (Italy)
Antonio Pifferi, INFM and INFN-CNR, Politecnico di Milano (Italy)
Paola Taroni, INFM and INFN-CNR, Politecnico di Milano (Italy)
Alessandro Torricelli, INFM and INFN-CNR, Politecnico di Milano (Italy)
Marco Ferrari, Univ. degli Studi dell'Aquila (Italy)
Valentina Quaresima, Univ. degli Studi dell'Aquila (Italy)

Published in SPIE Proceedings Vol. 4955:
Optical Tomography and Spectroscopy of Tissue V
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva M. Sevick-Muraca, Editor(s)

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