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Proceedings Paper

Application of high-pressure Raman spectroscopy to bone biomechanics
Author(s): Michael D. Morris; Olivia de Carmejane; Angela Carden; M. Kathleen Davis; Lars Stixrude; Mary Tecklenburg; Rupak M. Rajachar; David H. Kohn
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Paper Abstract

Compressive stress on bone, cartilage and other tissues accompanies normal activity. While the biomechanical properties of many tissues are reasonably well-understood at many levels of structure, surprisingly little is known at the ultrastructural and crystal lattice levels. We show how the use of diamond anvil cell Raman microspectroscopy enables a deeper understanding of the response of tissue to mechanical stress. We discuss the reversible responses of deproteinated and intact bone powders to hydrostatic pressure and compare these responses to those of a model compound, synthetic carbonated apatite.

Paper Details

Date Published: 22 July 2003
PDF: 10 pages
Proc. SPIE 4958, Advanced Biomedical and Clinical Diagnostic Systems, (22 July 2003); doi: 10.1117/12.477940
Show Author Affiliations
Michael D. Morris, Univ. of Michigan (United States)
Olivia de Carmejane, Univ. of Michigan (United States)
Angela Carden, Univ. of Washington (United States)
M. Kathleen Davis, Univ. of Michigan (United States)
Lars Stixrude, Univ. of Michigan (United States)
Mary Tecklenburg, Central Michigan Univ. (United States)
Rupak M. Rajachar, Univ. of Michigan (United States)
David H. Kohn, Univ. of Michigan (United States)

Published in SPIE Proceedings Vol. 4958:
Advanced Biomedical and Clinical Diagnostic Systems
Tuan Vo-Dinh; Warren S. Grundfest M.D.; David A. Benaron M.D.; Gerald E. Cohn, Editor(s)

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