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Proceedings Paper

Optical system to characterize the gross contractile response of a tissue-equivalent collagen matrix
Author(s): Jami Kern; S. Dan Dimitrijevisch; Tristan Jorge Tayag; Brandon D. Pitt; Tyler H. Summers; Casey G. Davis
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Paper Abstract

We present the theoretical operation and experimental results of a fiber optic interferometer, which we have used to measure the surface displacement of a collagen gel. Dispersed within the collagen gel are fibroblast cells. We describe a measurement system to assist in the detailed study of the biochemical and mechanical processes involved in fibroblast cell contraction. The interferometric system is non-contacting and offers a large dynamic range of measurement. Digital demodulation of a phase generated carrier results in an experimental sensitivity limit on the order of tens of nanometers with a measurement range of up to 2 mm. Computer-controlled data acquisition allows measurement of the contracting gel host over a period of several hours. We describe the optical interferometric system and present experimental results on a contracting collagen gel.

Paper Details

Date Published: 27 August 2003
PDF: 6 pages
Proc. SPIE 4961, Laser-Tissue Interaction XIV, (27 August 2003); doi: 10.1117/12.477915
Show Author Affiliations
Jami Kern, Univ. of North Texas Health Science Ctr. (United States)
S. Dan Dimitrijevisch, Univ. of North Texas Health Science Ctr. (United States)
Tristan Jorge Tayag, Texas Christian Univ. (United States)
Brandon D. Pitt, Texas Christian Univ. (United States)
Tyler H. Summers, Texas Christian Univ. (United States)
Casey G. Davis, Texas Christian Univ. (United States)

Published in SPIE Proceedings Vol. 4961:
Laser-Tissue Interaction XIV
Donald Dean Duncan; Steven L. Jacques; Sean J. Kirkpatrick; Andres Kriete, Editor(s)

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