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Proceedings Paper

OCT imaging of the larynx: a feasibility study
Author(s): Athanasios G. Bibas M.D.; Adrian Gh. Podoleanu; Radu G. Cucu; Mathias Bonmarin; George M. Dobre; Vicky Ward; Edward O'Dell; Aaron Boxer; Michael J. Gleeson; David A. Jackson
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Paper Abstract

Laryngeal cancer is the most common primary head and neck malignancy and the need for early identification is very important for early treatment. Outpatient fiberoptic examination of the larynx is often unreliable in differentiating between benign, pre-malignant and malignant lesions, and therefore surgeons often have to rely on biopsies for a definite diagnosis. This is an invasive procedure requiring general anaesthesia and may have a detrimental effect on patient’s voice. The aim of our study was to investigate the feasibility of optical coherence tomography in imaging of the larynx, which will lay the foundations for investigating its ability to differentiate between benign and malignant disease. Tissue specimens from normal larynges were imaged with a polarisation sensitive OCT system at 850 nm and a second OCT system at 1300 nm. Both OCT systems were capable of providing both B-scan (longitudinal OCT) images as well as C-scan (en-face OCT or at constant depth) images. Imaged specimens were processed with standard histopathological techniques and sectioned in the plane of the B-scan OCT images. Haematoxylin-Eosin stained specimens were compared to the OCT images. Preliminary results showed good correlation between OCT images and histology sections in normal tissues.

Paper Details

Date Published: 8 July 2003
PDF: 6 pages
Proc. SPIE 4956, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VII, (8 July 2003); doi: 10.1117/12.477886
Show Author Affiliations
Athanasios G. Bibas M.D., Guy's Hospital, King's College London (United Kingdom)
Adrian Gh. Podoleanu, Univ. of Kent (United Kingdom)
Radu G. Cucu, Univ. of Kent (United Kingdom)
Mathias Bonmarin, Univ. of Kent (United Kingdom)
George M. Dobre, Univ. of Kent (United Kingdom)
Vicky Ward, Guy's Hospital, King's College London (United Kingdom)
Edward O'Dell, Guy's Hospital, King's College London (United Kingdom)
Aaron Boxer, Opthalmic Technologies Inc. (Canada)
Michael J. Gleeson, Guy's Hospital, King's College London (United Kingdom)
David A. Jackson, Univ. of Kent (United Kingdom)

Published in SPIE Proceedings Vol. 4956:
Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VII
Valery V. Tuchin; Joseph A. Izatt; James G. Fujimoto, Editor(s)

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