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Proceedings Paper

Photoacoustic imaging of inhomogeneities embedded in breast tissue phantoms
Author(s): Srirang Manohar; Alexei Kharine; Johan G.C. van Hespen; Wiendelt Steenbergen; Frits F. M. de Mul; Ton G. J. M. van Leeuwen
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Paper Abstract

A novel photoacoustic breast phantom was developed using poly(vinyl alcohol) gel prepared by a simple technique that imparts optical scattering to the gel without the neccessity for scattering particles. Tumour simulating gel samples of suitable absorption coefficient were also prepared using a second technique, by adding appropriate quantities of dye at the time of formation; the samples were then cut into spheres. The optical absorption coefficient of the spheres was chosen as between 4 - 7 times that of breast tissue. A breast phantom with a thickness of 60 mm, embedded with such 'tumours' was developed for studying the applicability of photoacoustics in mammography. Time resolved photoacoustics, in a transmission mode, was used to image the inhomogeneities. Light excitation was from a liquid-light guide coupled Nd:YAG laser at 1064 nm, with a 5 ns pulse duration. The guide was mechanically scanned across the surface of the phantom, with the time-of-flight signals recorded using a PVDF based detector array. A modified delay and sum beamforming algorithm was used to reconstruct the photoacoustic sources. Results of these experiments are discussed.

Paper Details

Date Published: 1 July 2003
PDF: 12 pages
Proc. SPIE 4960, Biomedical Optoacoustics IV, (1 July 2003); doi: 10.1117/12.477778
Show Author Affiliations
Srirang Manohar, Univ. of Twente (Netherlands)
Alexei Kharine, Univ. of Twente (Netherlands)
Johan G.C. van Hespen, Univ. of Twente (Netherlands)
Wiendelt Steenbergen, Univ. of Twente (Netherlands)
Frits F. M. de Mul, Univ. of Twente (Netherlands)
Ton G. J. M. van Leeuwen, Univ. of Twente (Netherlands)
Academic Medical Ctr./Univ. of Amsterdam (Netherlands)

Published in SPIE Proceedings Vol. 4960:
Biomedical Optoacoustics IV
Alexander A. Oraevsky, Editor(s)

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