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Proceedings Paper

Terahertz spectroscopy of bound water in nano suspensions
Author(s): Samuel P. Mickan; Jonathon Dordick; Jesper Munch; Derek Abbott; Xi-Cheng Zhang
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Paper Abstract

The study of enzymatic protein molecules using terahertz time-domain spectroscopy (THz-TDS) has the potential to reveal molecular activity in real time without the use of labelling. Molecular hydration, or bound water, is a critical parameter in enzyme activity and THz-TDS measurements. For the first time we experimentally measure the terahertz-frequency response of nano-sized particles of protein and their level of molecular hydration. These measurements are valuable in understanding the terahertz response of biological systems and in studying the interaction between bound water and proteins.

Paper Details

Date Published: 14 November 2002
PDF: 13 pages
Proc. SPIE 4937, Biomedical Applications of Micro- and Nanoengineering, (14 November 2002); doi: 10.1117/12.477384
Show Author Affiliations
Samuel P. Mickan, Rensselaer Polytechnic Institute (United States)
Univ. of Adelaide (Australia)
Jonathon Dordick, Rensselaer Polytechnic Institute (United States)
Jesper Munch, Univ. of Adelaide (Australia)
Derek Abbott, Univ. of Adelaide (Australia)
Xi-Cheng Zhang, Rensselaer Polytechnic Institute (United States)

Published in SPIE Proceedings Vol. 4937:
Biomedical Applications of Micro- and Nanoengineering
Dan V. Nicolau, Editor(s)

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