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Proceedings Paper

Optical heterodyne surface plasmon resonance biosensor
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Paper Abstract

A novel optical heterodyne surface plasmon resonance (SPR) biosensor using Zeeman laser is proposed. There are two surface plasma waves (SPWs) being excited by two correlated P polarized waves in an SPR device of Kretschmann configuration. The two reflected P waves are optically heterodyned so that the amplitude of the heterodyned signal is proportional to the multiplication of two attenuated reflected P waves. The detection sensitivity and the dynamical range based on this amplitude sensitive method are enhanced. In the experiment, the kinetics between mouse IgG and anti-mouse IgG is obtained according to the sensograms of different concentrations of anti-mouse IgG. The detection sensitivity corresponding to 0.2 nM is achieved. In addition, a concentration of 5 ng/ml of protein G interacting with mouse IgG is measured successfully.

Paper Details

Date Published: 1 July 2003
PDF: 8 pages
Proc. SPIE 4957, Optical Fibers and Sensors for Medical Applications III, (1 July 2003); doi: 10.1117/12.476721
Show Author Affiliations
Chien Chou, National Yang-Ming Univ. (Taiwan)
Wen-chuan Kuo, National Yang-Ming Univ. (Taiwan)
Hsieh-Ting Wu, National Yang-Ming Univ. (Taiwan)

Published in SPIE Proceedings Vol. 4957:
Optical Fibers and Sensors for Medical Applications III
Israel Gannot, Editor(s)

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