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Proceedings Paper

Investigation of the thermal and tissue injury behavior in microwave thermal therapy of the porcine kidney
Author(s): Xiaoming He; Shawn Mcgee; James E. Coad M.D.; Franz R. Schmidlin M.D.; Paul Iaizzo; David J. Swanlund; Eric Rudie; Stan Kluge; John C. Bischof
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Paper Abstract

In this paper, we report the characterization of microwave therapy in normal porcine kidneys both in vitro and in vivo. This technology is being developed for eventual use in the treatment of small renal cell carcinomas (RCC) using minimally invasive procedures. Microwave energy was applied through an interstitial microwave probe (Urologix, Plymouth, MN) to the kidney cortex with involvement of the medulary region. The thermal histories at several locations were recorded. After treatment, the kidneys were bisected and tissue sections were prepared for histologic study at approximately the same depth as the thermal probe. Histologic cellular injury and microvascular stasis were quantitatively evaluated. Absolute rate kinetic models of cellular injury and vascular stasis were fit to the thermal and histologic data to determine the kinetic parameters. A 3-D finite element thermal model based on the Pennes Bioheat equation was developed and solved using a commercial software package (ANSYS, V5.7). The specific absorption rate (SAR) of the microwave probe was measured experimentally. This is the first thermal model validated using measured in vitro thermal histories and then used to determine the blood perfusion term in vivo.

Paper Details

Date Published: 10 June 2003
PDF: 12 pages
Proc. SPIE 4954, Thermal Treatment of Tissue: Energy Delivery and Assessment II, (10 June 2003); doi: 10.1117/12.476545
Show Author Affiliations
Xiaoming He, Univ. of Minnesota, Twin Cities (United States)
Shawn Mcgee, Univ. of Minnesota, Twin Cities (United States)
James E. Coad M.D., West Virginia Univ. (United States)
Franz R. Schmidlin M.D., Geneva Univ. Hospital (Switzerland)
Paul Iaizzo, Univ. of Minnesota, Twin Cities (United States)
David J. Swanlund, Univ. of Minnesota, Twin Cities (United States)
Eric Rudie, Urologix Inc. (United States)
Stan Kluge, Urologix Inc. (United States)
John C. Bischof, Univ. of Minnesota (United States)

Published in SPIE Proceedings Vol. 4954:
Thermal Treatment of Tissue: Energy Delivery and Assessment II
Thomas P. Ryan, Editor(s)

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