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Proceedings Paper

Patterning biomolecules and cells: an upside-down microlithography
Author(s): Dan V. Nicolau
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Paper Abstract

Spatially addressable immobilization of biomolecules and cells on patterned surfaces and microfabricated topographies has gained momentum in recent years. One major driving force behind this new impetus was the emergence of combinatorial DNA, protein and -soon- cell-based chips. The recent advances in New Generation Lithographies (NGL) as members with full rights in the panoply of microlithography techniques, automatically opened enormously large opportunities for microlithography engineering in the area of microarrays, which can be now seen as patterned chips. Despite all of these developments and related -yet to be fulfilled- opportunities, many other remained almost entirely unexplored. For instance, the intrinsic capability of the microlithographic materials -resists- to manipulate the surface properties via exposure to light has not been used for the patterning of biomolecules or cells. Also, other areas of classical microlithographic expertise, e.g. yield management, registration and alignment, and resolution enhancement are in many senses undiscovered by the bio-techniques for biomolecular and cellular patterning. This contribution will explore these hidden opportunities review the state of the art of biomolecular and cellular patterning through the glasses of a microlithographic engineer and it will explore the future areas where microlithography can contribute with the highest scientific, technical and commercial return-on-investment.

Paper Details

Date Published: 24 July 2002
PDF: 7 pages
Proc. SPIE 4690, Advances in Resist Technology and Processing XIX, (24 July 2002); doi: 10.1117/12.474213
Show Author Affiliations
Dan V. Nicolau, Swinburne Univ. of Technology (Australia)

Published in SPIE Proceedings Vol. 4690:
Advances in Resist Technology and Processing XIX
Theodore H. Fedynyshyn, Editor(s)

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