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Proceedings Paper

Self-localization of necrosis formation in tissue with tumor due to tissue response to local strong heating
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Paper Abstract

We analyze the necrosis growth due to thermal coagulation induced by laser light absorption and limited by heat diffusion into the surrounding live tissue. The tissue is assumed to contain a certain tumor in the undamaged tissue whereof the blood perfusion rate does not change during the action. By contrast, the normal tissue responds strongly to increase in the tissue temperature and the blood perfusion rate can grow by tenfold. We study in detail the necrosis formation under conditions typical for a real course of thermal therapy treatment, the duration of the action is taken about 5 minutes when a necrosis domain of size about or above 1 cm is formed. In particular, if the tumor size is sufficiently large, it is about 1 cm, and the tissue response is not too delayed, the delay time does not exceed 1 min, then there are conditions under which the relative volume of the damaged normal tissue is small in comparison with the tumor volume after the tumor is coagulated totally.

Paper Details

Date Published: 27 June 2002
PDF: 8 pages
Proc. SPIE 4617, Laser Tissue Interaction XIII: Photochemical, Photothermal, and Photomechanical, (27 June 2002); doi: 10.1117/12.472531
Show Author Affiliations
Ihor A. Lubashevsky, General Physics Institute (Russia)
Alexander V. Priezzhev, Moscow State Univ. (Russia)
Vasyl V. Gafiychuk, Institute for Applied Problems of Mechanics and Mathematics (Ukraine)
Bogdan Datsko, Institute for Applied Problems of Mechanics and Mathematics (Ukraine)

Published in SPIE Proceedings Vol. 4617:
Laser Tissue Interaction XIII: Photochemical, Photothermal, and Photomechanical
Steven L. Jacques; Donald Dean Duncan; Donald Dean Duncan; Sean J. Kirkpatrick; Sean J. Kirkpatrick; Andres Kriete; Andres Kriete, Editor(s)

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