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Proceedings Paper

Tomographic reconstruction of tissue chromophores using thermal wave imaging
Author(s): Sergey A. Telenkov; J. Stuart Nelson M.D.; Thomas E. Milner
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Paper Abstract

We demonstrate application of a thermal wave imaging technique to determine the physical dimensions and position of laser-heated chromophores in tissue. We demonstrate that utilization of a periodically modulated laser source for thermal wave excitation and coherent detection applied to each pixel may be used to compute images of thermal wave amplitude and phase at the laser modulation frequency and significantly improve quality of recorded radiometric images. A theoretical analysis utilizes solution of the three-dimensional heat conduction equation to simulate thermal wave images of amplitude and phase. Effects of non- specific laser excitation on the recorded thermal wave images have been analyzed. Results of numerical simulations are compared to that obtained from tissue phantoms and in- vivo samples.

Paper Details

Date Published: 27 June 2002
PDF: 7 pages
Proc. SPIE 4617, Laser Tissue Interaction XIII: Photochemical, Photothermal, and Photomechanical, (27 June 2002); doi: 10.1117/12.472506
Show Author Affiliations
Sergey A. Telenkov, Univ. of Texas at Austin (United States)
J. Stuart Nelson M.D., Beckman Laser Institute and Medical Clinic (United States)
Thomas E. Milner, Univ. of Texas at Austin (United States)

Published in SPIE Proceedings Vol. 4617:
Laser Tissue Interaction XIII: Photochemical, Photothermal, and Photomechanical
Steven L. Jacques; Donald Dean Duncan; Donald Dean Duncan; Sean J. Kirkpatrick; Sean J. Kirkpatrick; Andres Kriete; Andres Kriete, Editor(s)

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