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Proceedings Paper

Preparation and characterization of poly (ethylene glycol)-coated Stoeber silica nanoparticles for biomedical applications
Author(s): Raoul Kopelman; Hao Xu; Fei Yan; Eric E. Monson; Wei Tang; Randy Schneider; Martin A. Philbert
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Paper Abstract

Monodisperse, spherical, polyethylene glycol (PEG)-coated silica nanoparticles have been prepared in the size range of 50-350 nm, and their size distribution were characterized by SEM and multi-angle static light scattering experiments. The chemical binding of PEG to the silica nanoparticles was confirmed by IR spectroscopy. The biocompatibility of these PEGylated nanoparticles was also studied by non-specific protein binding tests and in-vivo toxicology studies in live animals. These silica nanoparticles, as a matrix for encapsulation of certain reagents, have been used for the fabrication of intracellular sensors and have potential for applications to in vivo diagnosis, analysis and measurements, due to their small physical size and their biocompatibility, both stemming from the specialized PEG coating.

Paper Details

Date Published: 21 June 2002
PDF: 11 pages
Proc. SPIE 4626, Biomedical Nanotechnology Architectures and Applications, (21 June 2002); doi: 10.1117/12.472104
Show Author Affiliations
Raoul Kopelman, Univ. of Michigan (United States)
Hao Xu, Univ. of Michigan (United States)
Fei Yan, Univ. of Michigan (United States)
Eric E. Monson, Univ. of Michigan (United States)
Wei Tang, Univ. of Michigan (United States)
Randy Schneider, Univ. of Michigan (United States)
Martin A. Philbert, Univ. of Michigan (United States)

Published in SPIE Proceedings Vol. 4626:
Biomedical Nanotechnology Architectures and Applications
Raymond P. Mariella Jr.; Michelle Palmer; Darryl J. Bornhop; Darryl J. Bornhop; Ramesh Raghavachari; Shuming Nie; Ramesh Raghavachari; Catherine J. Murphy; David A. Dunn; David A. Dunn; Raymond P. Mariella Jr.; Catherine J. Murphy; Dan V. Nicolau; Shuming Nie; Michelle Palmer; Ramesh Raghavachari, Editor(s)

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