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Proceedings Paper

Nanoparticle-based optical detection of molecular interactions of DNA-chip technology
Author(s): Wolfgang Fritzsche; Andrea Csaki; Robert Moeller
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Paper Abstract

We adapted the nanoparticle-labeling technique from microscopical applications for DNA-chip detection. Nanoparticles can be detected by simple optical means, and exhibit a high stability. So alternative optical readout devices can be applied for the detection of specific DNA- binding on microstructured spots of complementary, surface- immobilized capture DNA. Several devices were tested, and the binding of gold-labeled DNA to complementary and non- complementary sequences was investigated using optical detection of the gold-labeled substrates before and after silver enhancement.

Paper Details

Date Published: 21 June 2002
PDF: 6 pages
Proc. SPIE 4626, Biomedical Nanotechnology Architectures and Applications, (21 June 2002); doi: 10.1117/12.472097
Show Author Affiliations
Wolfgang Fritzsche, Institute for Physical High Technology Jena (Germany)
Andrea Csaki, Institute for Physical High Technology Jena (Germany)
Robert Moeller, Institute for Physical High Technology Jena (Germany)

Published in SPIE Proceedings Vol. 4626:
Biomedical Nanotechnology Architectures and Applications
Raymond P. Mariella Jr.; Michelle Palmer; Darryl J. Bornhop; Darryl J. Bornhop; Ramesh Raghavachari; Shuming Nie; Ramesh Raghavachari; Catherine J. Murphy; David A. Dunn; David A. Dunn; Raymond P. Mariella Jr.; Catherine J. Murphy; Dan V. Nicolau; Shuming Nie; Michelle Palmer; Ramesh Raghavachari, Editor(s)

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