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Proceedings Paper

Sensitivity estimation of spectroscopic optical coherence tomography
Author(s): Boris Hermann; Harald Sattmann; Kostadinka K. Bizheva; Boris Povazay; Angelika Unterhuber; Rainer Leitgeb; Leopold F. Schmetterer; Ferenc Krausz; Adolf Friedrich Fercher; Wolfgang Drexler
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Paper Abstract

This study aims to investigate the sensitivity of spectroscopic optical coherence tomography (OCT) to small changes in the absorption properties of the imaged object as well as to evaluate its ability to resolve spatial variations in the object's absorption coefficient. Spectroscopic OCT would have the advantage to provide spatially resolved spectroscopic information at multiple wavelengths across the available bandwidth of the light source in a single measurement. An ultrahigh resolution OCT system based on a Ti:sapphire source emitting in the range of 700 nm to 900 nm with an optical bandwidth of up to 165 nm was used to measure optical absorption of specially designed, non-scattering phantoms. High speed and high resolution digitization in combination with a Morlet wavelet transform was utilized to derive spectroscopic information from the full interference OCT data. Using a non scattering phantom, the preliminary results of the present work reveal the challenges that have to be overcome in order to extract spatially resolved quantitative spectroscopic information by OCT.

Paper Details

Date Published: 14 June 2002
PDF: 4 pages
Proc. SPIE 4619, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications VI, (14 June 2002); doi: 10.1117/12.470475
Show Author Affiliations
Boris Hermann, Univ. Wien (Austria)
Harald Sattmann, Univ. Wien (Austria)
Kostadinka K. Bizheva, Univ. Wien (Austria)
Boris Povazay, Univ. Wien (Austria)
Angelika Unterhuber, Femtolasers Produktions GmbH (Austria)
Rainer Leitgeb, Univ. Wien (Austria)
Leopold F. Schmetterer, Univ. Wien (Austria)
Ferenc Krausz, Technische Univ. Wien (Austria)
Adolf Friedrich Fercher, Univ. Wien (Austria)
Wolfgang Drexler, Univ. Wien (Austria)

Published in SPIE Proceedings Vol. 4619:
Coherence Domain Optical Methods in Biomedical Science and Clinical Applications VI
Valery V. Tuchin; Joseph A. Izatt; James G. Fujimoto, Editor(s)

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