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Proceedings Paper

Resonant cavity optical biosensors for the detection of nucleic acid hybridization
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Paper Abstract

Optical microcavities can be used to enhance the detection sensitivity of evanescent-wave fluorescence biosensors to the binding of a labeled analyte to a biospecific monolayer. The enhancement results form the buildup of intensity within the microcavity on resonance, which thereby increases fluorescence output from species specifically bound on the surface of the microcavity. Target studies are directed at nucleic acid hybridization, and initial results using high-Q dielectric microspheres have been obtained.

Paper Details

Date Published: 4 June 2002
PDF: 9 pages
Proc. SPIE 4625, Clinical Diagnostic Systems: Technologies and Instrumentation, (4 June 2002); doi: 10.1117/12.469793
Show Author Affiliations
Marc B. Airola, Univ. of Utah (United States)
Steve Blair, Univ. of Utah (United States)
Yan Chen, Univ. of Utah (United States)
Jack Davis, Univ. of Utah (United States)
Layne D. Williams, Univ. of Utah (United States)

Published in SPIE Proceedings Vol. 4625:
Clinical Diagnostic Systems: Technologies and Instrumentation
Gerald E. Cohn, Editor(s)

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