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Proceedings Paper

Morphology, properties, and dynamics of live cell in-vitro biomolecular interactions at surfaces and interfaces: analysis by scanning probe microscopy
Author(s): Sverre Myhra
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Paper Abstract

The scanning probe microscope (SPM) system is emerging as an increasingly important tool for non-intrusive interrogation of live cells in vitro. Its particular merit is that it retains complete functionality in a biocompatible fluid environment and can track the dynamics of cellular processes in real time and real space at nm resolution, as an imaging tool, and with pN force-sensing/imposing resolution, as an interaction tool. However, a live cell is a fragile object; meeting the requirements of non-intrusiveness presents a challenging task. The better-known recent contributions of SPM towards explanatory and predictive descriptions of biomolecular interactions at surfaces and interfaces will also be reviewed, and some recent attempts to reconfigure the SPM platform for demonstration of novel bio-device applications will be described.

Paper Details

Date Published: 14 November 2002
PDF: 12 pages
Proc. SPIE 4937, Biomedical Applications of Micro- and Nanoengineering, (14 November 2002); doi: 10.1117/12.469735
Show Author Affiliations
Sverre Myhra, Griffith Univ. (Australia)

Published in SPIE Proceedings Vol. 4937:
Biomedical Applications of Micro- and Nanoengineering
Dan V. Nicolau, Editor(s)

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