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Proceedings Paper

Monte Carlo simulation of NIR spectrum changes induced by variations of glucose concentration
Author(s): Masatoshi Tarumi; Mitsunori Shimada; Tomoya Murakami; Mamoru Tamura; Miho Shimada; Yukio Yamada
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Paper Abstract

We have analyzed the light propagation in tissue simulating media by a Monte Carlo method, using the estimated changes in the optical properties caused by variation of glucose concentration and temperature of the media. Using the calculated data, we have predicted the changes in the absorbance spectra caused by the change in glucose concentration in the absorbing and scattering medium. The predicted spectra have agreed very well with those obtained by the experiments. We have also studied the effects of the varying scattering coefficient on the spectra, and found that the changes in the absolute value and the wavelength dependency of the scattering coefficient are closely related to the changes in the observed spectra. In addition, we have calculated the changes in the absorbance spectra, when the glucose concentration and the temperature of glucose solution vary simultaneously. Using the multivariate analysis, we have extracted the glucose concentration accurately from the calculated absorbance spectra.

Paper Details

Date Published: 23 May 2002
PDF: 8 pages
Proc. SPIE 4624, Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II, (23 May 2002); doi: 10.1117/12.468324
Show Author Affiliations
Masatoshi Tarumi, Nikkiso Co., Ltd. (Japan)
Mitsunori Shimada, Nikkiso Co., Ltd. (Japan)
Tomoya Murakami, Nikkiso Co., Ltd. and Hokkaido Univ. (Japan)
Mamoru Tamura, Hokkaido Univ. (Japan)
Miho Shimada, Tokyo Institute of Psychiatry (Japan)
Yukio Yamada, Univ. of Electro-Communications and National Institute of Advanced Industrial Science and (Japan)

Published in SPIE Proceedings Vol. 4624:
Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II
Alexander V. Priezzhev; Gerard L. Cote, Editor(s)

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