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Proceedings Paper

Calibration-free methods in segmentation of cDNA microarray images
Author(s): Petri Vesanen; Mikko Tiainen; Olli P. Yli-Harja
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Paper Abstract

In this paper we consider the problem of complementary DNA (cDNA) microarray image segmentation for the purpose of relative spot intensity measurement. Our aim is to find reliable background and target areas for the measurement. In contrast to global and local thresholding techniques, we investigate methods insensitive to changes in intensity scale. We combine characteristics of binary hit-or-miss transform and assumption of ordinal scale measurements, thus leading to a rank-based shape detector. We also provide a segmentation scheme based on the detector and a training approach and goodness criteria for the detector.

Paper Details

Date Published: 22 May 2002
PDF: 12 pages
Proc. SPIE 4667, Image Processing: Algorithms and Systems, (22 May 2002); doi: 10.1117/12.467990
Show Author Affiliations
Petri Vesanen, Tampere Univ. of Technology (Finland)
Mikko Tiainen, Tampere Univ. of Technology (Finland)
Olli P. Yli-Harja, Tampere Univ. of Technology (Finland)

Published in SPIE Proceedings Vol. 4667:
Image Processing: Algorithms and Systems
Edward R. Dougherty; Jaakko T. Astola; Karen O. Egiazarian, Editor(s)

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