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Proceedings Paper

Algorithm for quantifying advanced carotid artery atherosclerosis in humans using MRI and active contours
Author(s): Gareth Adams; G. Wesley Vick III; Cassius Bordelon; William Insull M.D.; Joel Morrisett
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Paper Abstract

A new algorithm for measuring carotid artery volumes and estimating atherosclerotic plaque volumes from MRI images has been developed and validated using pressure-perfusion-fixed cadaveric carotid arteries. Our method uses an active contour algorithm with the generalized gradient vector field force as the external force to localize the boundaries of the artery on each MRI cross-section. Plaque volume is estimated by an automated algorithm based on estimating the normal wall thickness for each branch of the carotid. Triplicate volume measurements were performed by a single observer on thirty-eight pairs of cadaveric carotid arteries. The coefficient of variance (COV) was used to quantify measurement reproducibility. Aggregate volumes were computed for nine contiguous slices bounding the carotid bifurcation. The median (mean +/- SD) COV for the 76 aggregate arterial volumes was 0.93% (1.47% +/- 1.52%) for the lumen volume, 0.95% (1.06% +/- 0.67%) for the total artery volume, and 4.69% (5.39% +/- 3.97%) for the plaque volume. These results indicate that our algorithm provides repeatable measures of arterial volumes and a repeatable estimate of plaque volume of cadaveric carotid specimens through analysis of MRI images. The algorithm also significantly decreases the amount of time necessary to generate these measurements.

Paper Details

Date Published: 9 May 2002
PDF: 10 pages
Proc. SPIE 4684, Medical Imaging 2002: Image Processing, (9 May 2002); doi: 10.1117/12.467110
Show Author Affiliations
Gareth Adams, Baylor College of Medicine (United States)
G. Wesley Vick III, Baylor College of Medicine (United States)
Cassius Bordelon, Baylor College of Medicine (United States)
William Insull M.D., Baylor College of Medicine (United States)
Joel Morrisett, Baylor College of Medicine (United States)

Published in SPIE Proceedings Vol. 4684:
Medical Imaging 2002: Image Processing
Milan Sonka; J. Michael Fitzpatrick, Editor(s)

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