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Proceedings Paper

Sensing macromolecules with microelectronics
Author(s): F. Keith Perkins; L M Tender; S J Fertig; Martin C. Peckerar
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Paper Abstract

Biological macromolecules (such as proteins, DNA, and RNA) are the machinery of biological processes. Sensors enabling quantitative, real-time detection of these objects promise an enhanced understanding and management of disease and illness, with obvious application to medicine and public health. Ideally, these such biosensors would be useable in the field, at medical point of care, or even in vivo, all of which places where sample preparation would be minimal and use of labeling reagents (e.g., fluorescently labeled antibodies) not practical. In a collaboration between the Electronics Science and Technology Division and the Center for Bio/Molecular Science and Engineering we have developed a microelectronic biosensor capable of label-free detection of a variety of biological macromolecules. When fully realized and implemented as elements in an array format, this biosensor may enable low cost, simultaneous, real-time detection of thousands of target macromolecules from small sample volumes (10's of ?liters) or even in vivo. We describe here the construction and performance of an example sensor based on conventional siliconbased technology, as well as future applications.

Paper Details

Date Published: 24 July 2002
PDF: 15 pages
Proc. SPIE 4608, Nanostructure Science, Metrology, and Technology, (24 July 2002); doi: 10.1117/12.465477
Show Author Affiliations
S J Fertig
Martin C. Peckerar

Published in SPIE Proceedings Vol. 4608:
Nanostructure Science, Metrology, and Technology
Martin C. Peckerar; Michael T. Postek Jr., Editor(s)

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