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Proceedings Paper

Real-time optical monitoring of tissue vitality in vivo
Author(s): Avraham Mayevsky; Tamar Manor; Eliyahu Pevzner; Assaf Deutsch; Revital Etziony; Nava Dekel
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Paper Abstract

Evaluation of tissue O2 balance (Supply/Demand) could be done by monitoring in real-time 2 out of the 3 components of the tissue O2 balance equation. In our previous publication (Mayevsky et al, SPIE Vol. 4255:33-39, 2001) we had shown the use of the multiparametric monitoring approach in the neurosurgical operating room, using a device combined of laser Doppler flowmeter (LDF) and surface fluorometer reflectometer. The two instruments having two different light sources, were connected to the tissue via a combined bundle of optical fibers. In order to improve the correlation between tissue blood flow and mitochondrial NADH redox state, the new Tissue Spectroscope (TiSpec) that was designed has a single light source and a single bundle of optical fibers. Preliminary results show very clear correlation between TBF and NADH redox state. In addition, the reflected light at the excitation wavelength could be used as an indication for blood volume changes. The results obtained by the TiSpec enabled us to compare tissue O2 delivery (TBF) with O2 balance (NADH redox state) in the brain of gerbils and rats exposed to ischemia, anoxia and spreading depression. Real-time monitoring of the metabolic state of the tissue has immense potential during surgical procedures.

Paper Details

Date Published: 26 March 2002
PDF: 10 pages
Proc. SPIE 4616, Optical Fibers and Sensors for Medical Applications II, (26 March 2002); doi: 10.1117/12.463821
Show Author Affiliations
Avraham Mayevsky, Bar-Ilan Univ. and Vital Medical Ltd. (Israel)
Tamar Manor, Vital Medical Ltd. (Israel)
Eliyahu Pevzner, Vital Medical Ltd. (Israel)
Assaf Deutsch, Vital Medical Ltd. (Israel)
Revital Etziony, Vital Medical Ltd. (Israel)
Nava Dekel, Vital Medical Ltd. (Israel)

Published in SPIE Proceedings Vol. 4616:
Optical Fibers and Sensors for Medical Applications II
Israel Gannot, Editor(s)

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