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Proceedings Paper

Photodynamic therapy of different photosensitizers in leukemia
Author(s): Sujuan Zhang; Zhenxi Zhang; Dazong Jiang
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Paper Abstract

Photodynamic therapy (PDT), a cancer treatment using a photosensitizer and visible light has been applied to treatment of blood cancer-leukemia. The effect of PDT may be modulated by the leukemia cell type; the photosensitizer's type, dose, dose rate changes; the incubation time; the light wavelength, dosage, dose rate change; the conjugation of photosensitizers to variety subcellular target: cell membrane, mitochondia, lipoprotein or liposome; the addition of chemotherapeutic agents et al. Many reports in the current literature are confusing and often apparently contradictory. In this article, we have attempted to conduct and present a comprehensive review of this rapidly expanding novel field in a range of photosensitizers. Cell types, photosensitizers, treatment conditions and mechanism of PDT are considered. Nonetheless, there is ample ground for optimism, and such knowledge as we already have should effectively underpin the clinical research that is ongoing.

Paper Details

Date Published: 12 April 2002
PDF: 9 pages
Proc. SPIE 4536, International Workshop on Photonics and Imaging in Biology and Medicine, (12 April 2002); doi: 10.1117/12.462525
Show Author Affiliations
Sujuan Zhang, Xi'an Jiaotong Univ. (China)
Zhenxi Zhang, Xi'an Jiaotong Univ. (China)
Dazong Jiang, Xi'an Jiaotong Univ. (China)

Published in SPIE Proceedings Vol. 4536:
International Workshop on Photonics and Imaging in Biology and Medicine
Qingming Luo; Britton Chance; Valery V. Tuchin, Editor(s)

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