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Proceedings Paper

Optimum procedure for construction of spectral classification algorithms for medical diagnosis
Author(s): Catherine A. Kendall; Hugh Barr M.D.; Neil Shepherd; Nicholas Stone
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Paper Abstract

Optical spectroscopic detection of early malignancy is becoming more widely accepted in academic circles, however much work remains to be done before full recognition by the medical community is achieved. The majority of published studies to date have demonstrated the potential of optical diagnosis techniques using small sample numbers in a selected patient population. Many are completed without a solid understanding of the shortcomings of histopathology, the 'gold standard' for cancer detection. For the development of a new technique to improve diagnosis it is vital that more rigorous protocols are employed in large-scale clinical trials. The prospect of utilizing NIR-Raman spectroscopy for the analysis of neoplastic gastrointestinal tissue has been thoroughly explored by a multi-disciplinary team including surgeons, pathologists, and spectroscopists. This study demonstrates the need for rigorous experimental protocols and histopathological analysis by a panel of expert pathologists. Measurements of tissue specimens from nine different pathological groups describing the full spectrum of disease in the oesophagus have been made. Only homogeneous samples with consensus pathology opinion were used to construct a training data set of Raman spectra. Models were constructed using multivariate analysis techniques and tested using cross-validation.

Paper Details

Date Published: 27 March 2002
PDF: 7 pages
Proc. SPIE 4614, Biomedical Vibrational Spectroscopy II, (27 March 2002); doi: 10.1117/12.460791
Show Author Affiliations
Catherine A. Kendall, Cranfield Postgraduate Medical School (United Kingdom)
Hugh Barr M.D., Cranfield Postgraduate Medical School and Gloucestershire Royal Hospital (United Kingdom)
Neil Shepherd, Cranfield Postgraduate Medical School and Gloucestershire Royal Hospital (United Kingdom)
Nicholas Stone, Cranfield Postgraduate Medical School (United Kingdom)

Published in SPIE Proceedings Vol. 4614:
Biomedical Vibrational Spectroscopy II
Anita Mahadevan-Jansen; Henry H. Mantsch; Gerwin J. Puppels, Editor(s)

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