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Proceedings Paper

Noninvasive optical monitoring of rat brain and effects of the injection of tracers for blood flow measurements
Author(s): Raphael Sablong; E. Grillon; Oliver Hugon; Jacques Derouard
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Paper Abstract

Near infrared spectroscopy using either broad band reflectance spectrophotometry or monochromatic illumination has been carried out to monitor non invasively the changes of the concentrations of chromophores in rat brain induced by the intravenous injection of various contrast agents (indocyanine green, ultrasmall magnetic particles suspension, albumine, dextran, or saline solution alone). Depending of the wavelength and of the absorption spectrum of the injected compound the bolus can be seen either by a decrease or an increase of the transmitted light, this latter due to the induced dilution of the blood by the bolus. We suggest that this could be used to determine the arterial input function of the contrast agent needed to perform absolute cerebral blood flow imaging by nuclear magnetic resonance.

Paper Details

Date Published: 31 October 2001
PDF: 6 pages
Proc. SPIE 4432, Diagnostic Optical Spectroscopy in Biomedicine, (31 October 2001); doi: 10.1117/12.447142
Show Author Affiliations
Raphael Sablong, Univ. Joseph Fourier (France)
E. Grillon, CHU Grenoble (France)
Oliver Hugon, Univ. Joseph Fourier (France)
Jacques Derouard, Univ. Joseph Fourier and CHU Grenoble (France)

Published in SPIE Proceedings Vol. 4432:
Diagnostic Optical Spectroscopy in Biomedicine
Theodore G. Papazoglou; Georges A. Wagnieres, Editor(s)

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