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Proceedings Paper

Optical biopsy for the diagnosis of dysplasia in Barrett's oesophagus
Author(s): David C. O. Pickard; Irving J. Bigio; Stephen G. Bown; Laurence B. Lovat; Paul M. Ripley; Marco Novelli
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Paper Abstract

Barrett's oesophagus is an increasingly common pre-cancerous condition, which occurs in patients suffering from acid reflux into their gullet. Biopsies must be taken from patients diagnosed with this condition regularly to pick up signs of pre-cancerous changes. Elastic scattering spectroscopy offers the possibility of distinguishing between benign and pre-cancerous changes in the lower oesophagus with a relatively simple optical measurement. This optical biopsy is correlated with a conventional histopathological specimen obtained at the same point. It is shown that to a relatively high degree of sensitivity and specificity it is possible to distinguish between pre-malignant patches, benign lesions and normal tissue.

Paper Details

Date Published: 31 October 2001
PDF: 7 pages
Proc. SPIE 4432, Diagnostic Optical Spectroscopy in Biomedicine, (31 October 2001); doi: 10.1117/12.447133
Show Author Affiliations
David C. O. Pickard, Univ. College London Medical School (United Kingdom)
Irving J. Bigio, Boston Univ. (United States)
Stephen G. Bown, Univ. College London Medical School (United Kingdom)
Laurence B. Lovat, Univ. College London Medical School (United Kingdom)
Paul M. Ripley, Los Alamos National Lab. (United States)
Marco Novelli, Univ. College London Medical School (United Kingdom)

Published in SPIE Proceedings Vol. 4432:
Diagnostic Optical Spectroscopy in Biomedicine
Theodore G. Papazoglou; Georges A. Wagnieres, Editor(s)

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