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Proceedings Paper

Cellular modes of adaptation to environmental changes
Author(s): William R. Huckle
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Paper Abstract

Eukaryotic cells are remarkably adaptable entities. Whether embedded in solid tissues or freely suspended in blood or other fluids, cells principally exist in an aqueous environment but maintain a hydrophobic barrier, the plasma membrane, across which changes in the environment are detected. Utilizing specialized macromolecular components, cells can sense changes in temperature, hydrostatic pressure, oxygen tension, shear, shape, osmolarity, pH, electrical potential, electromagnetic radiation, and the concentrations of specific chemical compounds. Modes of response are equally varied, ranging from rapid secretion of stored substances to irreversible functional differentiation to self-destruction. Recent research has elucidated many of the enzymatic and genetic programs that accomplish these adaptations and suggests novel targets for therapeutic intervention.

Paper Details

Date Published: 23 October 2001
PDF: 7 pages
Proc. SPIE 4512, Complex Adaptive Structures, (23 October 2001); doi: 10.1117/12.446756
Show Author Affiliations
William R. Huckle, Virginia-Maryland Regional College of Veterinary Medicine (United States)

Published in SPIE Proceedings Vol. 4512:
Complex Adaptive Structures
William B. Spillman Jr., Editor(s)

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