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Proceedings Paper

Visualization of electron transfer interactions of membrane proteins
Author(s): Suguru Kawato
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Paper Abstract

To visualize electron transfer interactions of proteins in the cellular nieinbrane, we have developed a polarized laser flash-induced anisotropy decay imaging. The time-resolved anisotropy is particularly sensitive to protein-protein interactions. This technique has been successfully applied to examine formation and dissociation of electron transfer complex in adrenal cortex and liver. Electron transfer plays a significant role for steroid hormone synthesis from cholesterol in adrenalcortex and for drug metabolism in liver such as detoxification of chemical compounds. Several redox partners perticipate in dynamic electron transfer interactions. The terminal enzyme cytochrome P-450 receives electrons to activate molecular oxygen, resulting in hydroxylation of various substrates.

Paper Details

Date Published: 1 August 1991
PDF: 5 pages
Proc. SPIE 1429, Holography, Interferometry, and Optical Pattern Recognition in Biomedicine, (1 August 1991); doi: 10.1117/12.44671
Show Author Affiliations
Suguru Kawato, Univ. of Tokyo/Komaba (Japan)

Published in SPIE Proceedings Vol. 1429:
Holography, Interferometry, and Optical Pattern Recognition in Biomedicine
Halina Podbielska M.D., Editor(s)

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