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Proceedings Paper

Real-time atomic force fluorescence microscopy on living cells
Author(s): Jens Struckmeier; Erk Klopp; Matthias Born; Martin R. Hofmann; Damaris Rink; David B. Jones; Stefan Ecke; Hans-Juergen Butt
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Paper Abstract

The reaction of bone cells after mechanical stimulation is a key issue in understanding the origins of osteoporosis. We investigate mechanical stimulation of osteoblasts and their reaction with a new combination of an atomic force apparatus with a fluorescence microscope. First measurements on the mechanically induced calcium response of osteoblasts are presented. The average threshold force for stimulation is 300nN and the dynamics of the calcium response is in the several tens of seconds range.

Paper Details

Date Published: 24 October 2001
PDF: 8 pages
Proc. SPIE 4434, Hybrid and Novel Imaging and New Optical Instrumentation for Biomedical Applications, (24 October 2001); doi: 10.1117/12.446671
Show Author Affiliations
Jens Struckmeier, Philipps Univ. of Marburg (United States)
Erk Klopp, Philipps Univ. of Marburg (Germany)
Matthias Born, Philipps Univ. of Marburg (Germany)
Martin R. Hofmann, Philipps Univ. of Marburg (Germany)
Damaris Rink, Philipps Univ. of Marburg (Germany)
David B. Jones, Philipps Univ. of Marburg (Germany)
Stefan Ecke, Univ. Gesamthochschule Siegen (Germany)
Hans-Juergen Butt, Univ. Gesamthochschule Siegen (Germany)

Published in SPIE Proceedings Vol. 4434:
Hybrid and Novel Imaging and New Optical Instrumentation for Biomedical Applications
Albert-Claude Boccara; Alexander A. Oraevsky, Editor(s)

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