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Proceedings Paper

Blood immersion and sedimentation study using OCT technique
Author(s): Valery V. Tuchin; Xiangqun Xu; Ruikang K. Wang
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Paper Abstract

The refractive index matching (immersion) method is used to enhance the optical penetration depth of whole blood in in vitro study by the NIR optical coherence tomography (OCT) technique. It was found that for tested agents (glucose, dextrans, propylene glycol, and trazograph) the enhancement of penetration was from 20 % to 150 %. In the blood sedimentation study, regular or irregular oscillations or jumps of the RBC/plasma boundary were observed. The one-minute time period of regular oscillations correlated well with the kinetics of the aggregation process. For the first time OCT images of blood aggregates in a small plastic vessel were observed. Presented results have potentials in intra-vascular OCT imaging and in blood sedimentation and aggregation studies for diagnostic purposes.

Paper Details

Date Published: 25 October 2001
PDF: 10 pages
Proc. SPIE 4597, Biophotonics Instrumentation and Analysis, (25 October 2001); doi: 10.1117/12.446639
Show Author Affiliations
Valery V. Tuchin, Saratov State Univ. (Russia)
Xiangqun Xu, Keele Univ. (United Kingdom)
Ruikang K. Wang, Keele Univ. (United Kingdom)

Published in SPIE Proceedings Vol. 4597:
Biophotonics Instrumentation and Analysis
Arthur E. T. Chiou; Halina Podbielska M.D.; Steven L. Jacques, Editor(s)

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