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Proceedings Paper

Spectroscopic studies of second-generation sensitizers and their photochemical reactions in liposomes and cells
Author(s): Benjamin Ehrenberg; Eitan Gross; Adina Lavi; Fred M. Johnson; Zvi Malik
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Paper Abstract

The photosensitization mechanism and kinetics of hematoporphyrin derivative (HPD), photofrin II (PF-II) and Zn2+-phthalocyanine tetrahydroxyl (ZnPC) are compared with the newly introduced sensitizers Zn2+ and Mg2+-tetrabenzoporphyrin (ZnTBP and MgTBP), in lipid vesicles. 9,10-dimethyl anthracene was used as a fluorescent target for singlet oxygen-mediated photosensitization. From the kinetics the quantum yield of singlet oxygen generation was calculated. MgTBP is compared with hematoporphyrin for the ability to photodamage bacterial cells and human cancer cells. MgTBP was found to have a comparable capacity for such a biological effect.

Paper Details

Date Published: 1 June 1991
PDF: 8 pages
Proc. SPIE 1426, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques, (1 June 1991); doi: 10.1117/12.44078
Show Author Affiliations
Benjamin Ehrenberg, Bar-Ilan Univ. (Israel)
Eitan Gross, Bar-Ilan Univ. (Israel)
Adina Lavi, Bar-Ilan Univ. (Israel)
Fred M. Johnson, Bar-Ilan Univ. (Israel)
Zvi Malik, Bar-Ilan Univ. (Israel)

Published in SPIE Proceedings Vol. 1426:
Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques
Thomas J. Dougherty, Editor(s)

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