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Proceedings Paper

Radiolabeled red blood cells for the direct measurement of the blood flow kinetics in experimental tumors after photodynamic therapy
Author(s): Benoit Paquette; Jacques Rousseau; Rene Ouellet; Johan E. van Lier
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Paper Abstract

Red blood cells from BALB/c mice were labeled with short-lived (gamma) -emitting 99mTc and injected in EMT-6 tumor-bearing animals as a probe for the blood circulation. 99mTc-concentrations in light-exposed versus non-treated tumors were established for different photosensitizers at various dye doses and time intervals post-photodynamic therapy. At minimal dye doses for tumor cure, Photofrin IITM induced a doubling of the tumor radioactivity within the first hour post-PDT, followed by a marked decrease in the 99mTc-concentration at 24 hours post PDT. This pattern is characteristic of extensive hemorrhage followed by occlusion of the blood vessels. Under similar conditions the mono- and tetrasulfonated zinc phthalocyanines induced tumor response without prolonged effects on the tumor radioactivity levels. Accordingly, with the latter sensitizers, indirect cell kill via obstruction of the blood supply does not appear to constitute a major factor in eliciting a tumor response.

Paper Details

Date Published: 1 June 1991
PDF: 5 pages
Proc. SPIE 1426, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques, (1 June 1991); doi: 10.1117/12.44077
Show Author Affiliations
Benoit Paquette, Univ. of Sherbrooke (Canada)
Jacques Rousseau, Univ. of Sherbrooke (Canada)
Rene Ouellet, Univ. of Sherbrooke (Canada)
Johan E. van Lier, Univ. of Sherbrooke (Canada)

Published in SPIE Proceedings Vol. 1426:
Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques
Thomas J. Dougherty, Editor(s)

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