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Proceedings Paper

Effectiveness of porphyrin-like compounds in photodynamic damage of atherosclerotic plaque
Author(s): Viacheslav N. Zalessky M.D.; Vladimir Bobrov; Igor Michalkin; Vitaliy Trunov
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Paper Abstract

Porphyrin-like compounds such as tetra-(4 sulfonatophenyl) porphine (TSPP), chlorin-e6 derivative (CED) and tetrasulfophthalocyanin (TSPC) are photosensitizing agents that absorbed light at 630 nm, 657 nm and 625 nm, respectively, and bind preferentially to atherosclerotic plaque. Porphyrin-treated human cadaveric aorta was compared with untreated aorta using several techniques: the absorptive spectrophotometry which has demonstrated the distinct absorptive peaks at 630 nm, 657 nm, 625 nm in porphyrin-treated plaque which were absent in untreated normal aorta; the fluorescence microscopy, which has shown that the treated atheroma acquired the characteristic fluorescence of porphyrin under ultraviolet light. Because of the porphyrin''s unique property, porphyrin-treated and untreated aorta was exposed to red laser radiation at a wavelength of 632.8 nm. It was found that enhanced photoalteration of porphyrin-treated compared with untreated atheroma. Histologic analysis of the depth of tissue penetration of equal amounts of laser radiation has demonstrated more pronounced photosensitizing effect in TSPC-treated plaque compared with CED-, TSPP-, and untreated plaques. This study demonstrates a potential of tetrasulfophthalocyanin for selective alteration of atheroma by He-Ne laser radiation.

Paper Details

Date Published: 1 June 1991
PDF: 8 pages
Proc. SPIE 1426, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques, (1 June 1991); doi: 10.1117/12.44055
Show Author Affiliations
Viacheslav N. Zalessky M.D., Kavetsky Institute for Oncology Problems (Ukraine)
Vladimir Bobrov, Postgradual Medical Institute (Ukraine)
Igor Michalkin, Kavetsky Institute for Oncology Problems (Ukraine)
Vitaliy Trunov, Kavetsky Institute for Oncology Problems (Ukraine)

Published in SPIE Proceedings Vol. 1426:
Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques
Thomas J. Dougherty, Editor(s)

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