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Proceedings Paper

Application of conjugated heparin-albumin microparticles with laser-balloon angioplasty: a potential method for reducing adverse biologic reactivity after angioplasty
Author(s): Sourav K. Kundu; Linda P. McMath; Jonathan T. Zaidan; J. Richard Spears M.D.
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Paper Abstract

Laser-balloon angioplasty (LBA) may potentially be used for local application of pharmacologically active agents which will reduce thrombogenic and proliferative responses after the angioplasty. In this study, the feasibility of applying covalently conjugated heparin- albumin microparticles onto arterial luminal surface was demonstrated. The covalent linkages were formed by reaction with 1-ethyl-3-dimethyl-aminopropyl-carbodiimide (EDC), and the resultant conjugates were used for preparation of microparticles by employing standard emulsification and heat-crosslinking techniques. The heparin release rate from the microparticles was found to be dependent upon the degree of crosslinking. When a thin coagulum of a suspension of microparticles was formed with heat on a glass surface, the treated surface demonstrated resistance to clot formation in contact with non-anticoagulated blood. A suspension of the microparticles applied during laser-balloon angioplasty onto the luminal surface of dog carotid and femoral arteries showed persistence for up to one week without thrombus formation or occlusion of the vessel. Since the rate of biodegradation is primarily dictated by the extent of crosslinking, an optimal degree of thermal denaturation will permit longer persistence of the carrier while allowing adequate release of the entrapped pharmacologic agent. A variety of antithrombotic and antiinflammatory agents are being considered as candidate bioprotective materials for local application after angioplasty.

Paper Details

Date Published: 1 May 1991
PDF: 7 pages
Proc. SPIE 1425, Diagnostic and Therapeutic Cardiovascular Interventions, (1 May 1991);
Show Author Affiliations
Sourav K. Kundu, Harper Hospital and Wayne State Univ. School of Medicine (United States)
Linda P. McMath, Harper Hospital and Wayne State Univ. School of Medicine (United States)
Jonathan T. Zaidan, Harper Hospital and Wayne State Univ. School of Medicine (United States)
J. Richard Spears M.D., Harper Hospital and Wayne State Univ. School of Medicine (United States)

Published in SPIE Proceedings Vol. 1425:
Diagnostic and Therapeutic Cardiovascular Interventions
George S. Abela M.D., Editor(s)

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