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Proceedings Paper

Detection of DNA hybridization with surface plasmon resonance biosensor: comparison of immobilization of oligonucleotides by ssDNA and dsDNA
Author(s): Meng Wu; Zhihong Lin; Vladimir Mirsky; Otto S. Wolfbeis
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Paper Abstract

In this research, a surface-plasmon resonance biosensor for nucleic acid detection was constructed, optimized and characterized. The kinetic response on hybridization was also studied. The biosensor was use as a platform for the study of the surface coverage control by single-strand or double-strand oligonucleotide immobilization. The dsDNA immobilization and offers a new way to surface coverage control for the nucleic acid biosensor construction.

Paper Details

Date Published: 14 September 2001
PDF: 4 pages
Proc. SPIE 4414, International Conference on Sensor Technology (ISTC 2001), (14 September 2001); doi: 10.1117/12.440180
Show Author Affiliations
Meng Wu, Univ. of Regensburg and Huazhong Univ. of Science and Technology (Germany)
Zhihong Lin, Huazhong Univ. of Science and Technology (China)
Vladimir Mirsky, Univ. of Regensburg (Germany)
Otto S. Wolfbeis, Univ. of Regensburg (Germany)

Published in SPIE Proceedings Vol. 4414:
International Conference on Sensor Technology (ISTC 2001)
Yikai Zhou; Shunqing Xu, Editor(s)

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