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Proceedings Paper

Diagnosis of atherosclerotic tissue by resonance fluorescence spectroscopy
Author(s): Walter Neu; Karl Konstantin Haase M.D.; Christian Tischler M.D.; Ralf Nyga; Karl R. Karsch M.D.
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Paper Abstract

Resonantly enhanced fluorescence emission induced by a tunable dye laser can be used for the identification of ablated atherosclerotic tissue. This method has been tested with anorganic samples exposed to air and to saline solution. A XeCl excimer laser pulse ((lambda) = 308 nm), delivered by a fused silica optical fiber, causes an efficient ablation of the irradiated samples. The wavelength of the narrow-band dye laser radiation is set to a strong transition of a specific species to be detected in the ablation plume. Taking into account the formation of the plume, the dye laser pulse is applied with a certain delay in order to excite resonantly the selected species in the plume. The resulting resonance fluorescence then is guided by optical fibers to an optical multi-channel analyzer system. Compared to the broad-band fluorescence during excimer laser ablation the resonance fluorescence signal shows a distinct and easily detectable sharp peak. The signal-to-background ratio is improved by one order of magnitude.

Paper Details

Date Published: 1 May 1991
PDF: 9 pages
Proc. SPIE 1425, Diagnostic and Therapeutic Cardiovascular Interventions, (1 May 1991); doi: 10.1117/12.44014
Show Author Affiliations
Walter Neu, Laser-Lab. Goettingen (Germany)
Karl Konstantin Haase M.D., Eberhard Karls Univ. Medical Clinic (Germany)
Christian Tischler M.D., Eberhard Karls Univ. Medical Clinic (Germany)
Ralf Nyga, Laser-Lab. Goettingen (Germany)
Karl R. Karsch M.D., Eberhard Karls Univ. Medical Clinic (Germany)

Published in SPIE Proceedings Vol. 1425:
Diagnostic and Therapeutic Cardiovascular Interventions
George S. Abela M.D., Editor(s)

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