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Proceedings Paper

Kinetic models for coagulation processes: determination of rate coefficients in vivo
Author(s): John Anthony Pearce; Wai-Fung Cheong; Kirit Pandit; Tom J. McMurray; Sharon L. Thomsen M.D.
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Paper Abstract

Kinetic models of thermal damage in tissues can be used to describe histologic end points obtained with laser irradiation. In this study, thermographic measurements of skin surface temperature distributions during laser impingement were used to derive a temperature history for the lesion site. Lesions were evaluated at 48 h after laser irradiation to determine the radius of purpura formation. The temperature histories at the maximum radius of purpura formation (threshold temperatures) were analyzed and plotted on Arrhenius axes to estimate rate coefficients for the process. As expected, transient in vivo thermal history data yielded a noisy Arrhenius plot; however, estimates of the appropriate rate coefficients for purpura formation in vivo could be made.

Paper Details

Date Published: 1 June 1991
PDF: 7 pages
Proc. SPIE 1422, Lasers in Dermatology and Tissue Welding, (1 June 1991);
Show Author Affiliations
John Anthony Pearce, Univ. of Texas/Austin (United States)
Wai-Fung Cheong, Boston Univ. School of Medicine (United States)
Kirit Pandit, Univ. of Texas/Austin (United States)
Tom J. McMurray, Univ. of Texas/Austin (United States)
Sharon L. Thomsen M.D., Univ. of Texas M.D. Anderson Cancer Ctr. (United States)

Published in SPIE Proceedings Vol. 1422:
Lasers in Dermatology and Tissue Welding
Oon Tian Tan M.D.; Rodney A. White M.D.; John V. White M.D., Editor(s)

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