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Proceedings Paper

Microinvasive laser surgery for laryngeal carcinoma
Author(s): Jinping Lai; Zhengde Tao; Jianyun Xiao; Junli Luo; Xianghui Chen; Suping Zhao; Christian Betz
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Paper Abstract

Objective: To investigate the effectiveness of microinvasive Nd:YAG laser surgery in case of early stage laryngeal carcinoma as well as it's effect on the cellular immune function of the tumor-bearing hosts. Material and Method: Thirty-seven patients with glottic Tis or T1 SCC were treated by fiberoptic laryngoscopic Nd:YAG laser surgery. Both before and after therapy, serum levels of soluble interleukin-2 receptor (SIL-2R) and interleukin- 2(IL-2) as well as the NK activity were determined via double-antibody sandwich technique, tritiated thymidine- deoxyribonucleoside incorporation and iodine 125-uridine- deoxyribunocleoside release technique, respectively. Result: All 37 patients tolerated the procedure well. A 3-8 year follow up in a subgroup of 31 patients resulted in a estimated cure rate of 87.1% (27/31). The posttherapy serum levels of SIL-2R were significantly declined (p<0.001), while those of IL-2 and NK activity were significantly elevated (p<0.001) as compared with those detected pretherapeutically. Conclusion: Therapy with fiberoptic laryngoscopic Nd:YAG laser surgery is simple, safe, effective and microinvasive for the patients with early stage laryngeal carcinoma and has an immuno-enhancing effect on its host.

Paper Details

Date Published: 22 August 2001
PDF: 5 pages
Proc. SPIE 4427, Imaging of Tissue Structure and Function, (22 August 2001); doi: 10.1117/12.438422
Show Author Affiliations
Jinping Lai, Xiang Ya Hospital/Central South Univ. (China)
Zhengde Tao, Xiang Ya Hospital/Central South Univ. (China)
Jianyun Xiao, Xiang Ya Hospital/Central South Univ. (China)
Junli Luo, Xiang Ya Hospital/Central South Univ. (China)
Xianghui Chen, Xiang Ya Hospital/Central South Univ. (China)
Suping Zhao, Xiang Ya Hospital/Central South Univ. (China)
Christian Betz, Univ. of Munich (Germany)

Published in SPIE Proceedings Vol. 4427:
Imaging of Tissue Structure and Function
Valery V. Tuchin; Qingming Luo; Sergey S. Ulyanov, Editor(s)

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