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Proceedings Paper

3D simultaneous reconstruction of absorption and scattering coefficients in time-resolved optical tomography
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Paper Abstract

A Newton-Raphson inversion algorithm is extended for simultaneous absorption and scattering reconstruction of full 3-dimensional (3D) time-resolved diffuse optical tomography, which is based on efficient computation of Jacobian matrix of the forward model, and uses Algebraic Reconstruction Technique as the linear inversion tool. We validate the algorithm using both numerically simulated data from 3D finite-element discretization model of a tissue-like cylindrical phantom, embedding three inhomogeneities with different geometric and optical properties, as well as experimental measurements for a 3-D structural cylindrical phantom containing three absorptive rods, by means of fan-beam scanning mode. Our results show that a full 3D simultaneous reconstruction of absorption and scattering in turbid medium can be achieved with highly reasonable quality provided that the diffusive nature of light propagation in tissue is appropriately modeled, and temporal information of the measurements effectively employed.

Paper Details

Date Published: 29 June 2001
PDF: 8 pages
Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); doi: 10.1117/12.434526
Show Author Affiliations
Feng Gao, Mechanical Engineering Lab. and Univ. Louis Pasteur (Japan)
Patrick Poulet, Univ. Louis Pasteur (France)
Yukio Yamada, Mechanical Engineering Lab. (Japan)

Published in SPIE Proceedings Vol. 4250:
Optical Tomography and Spectroscopy of Tissue IV
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva Marie Sevick-Muraca, Editor(s)

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