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Proceedings Paper

Optimizing single-projection linear tomographic optical breast imaging
Author(s): Lai Wang; Quan Zhang; Thomas J. Brukilacchio; David A. Boas
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Paper Abstract

Optimization of the systems and reconstruction techniques is important for good optical breast imaging. Quantitative and objective assessments of the quality of the reconstructed image and the detection sensitivity are required to optimize single projection optical imaging. In this paper, the detection sensitivity was estimated by the contrast to noise ratio, and the quality of an image is evaluated using resolution, image noise, positional error, and quantitative accuracy. The expressions of these evaluating parameters were set up and analyzed by simulation. Using the quantitative assessment parameters we developed, we present a sensitivity and accuracy analysis of the Truncated Singular Value Decomposition (TSVD) method applied to optical breast imaging in transmission mode. The results indicate that the higher spatial resolution and improved quantitative accuracy obtained by decreasing the TSVD regularization parameter (i.e. the number of singular values used in the matrix inversion) must be balanced against the concomitant increase in image noise. Other parameters needs to be optimized including probe geometry, voxel size were also analyzed.

Paper Details

Date Published: 29 June 2001
PDF: 16 pages
Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); doi: 10.1117/12.434519
Show Author Affiliations
Lai Wang, Tufts Univ. (United States)
Quan Zhang, Massachusetts General Hospital/Harvard Medical School (United States)
Thomas J. Brukilacchio, Tufts Univ. (United States)
David A. Boas, Massachusetts General Hospital/Harvard Medical School and Tufts Univ. (United States)

Published in SPIE Proceedings Vol. 4250:
Optical Tomography and Spectroscopy of Tissue IV
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva Marie Sevick-Muraca, Editor(s)

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