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Proceedings Paper

Near-infrared optical imager for cerebral blood flow and oxygenation detection
Author(s): Ichiro Oda; Yukihisa Wada; Sadao Takeuchi; Yukio Oikawa; Naojumi Sakauchi; Yasunobu Ito; Ikuo Konishi; Yoshio Tsunazawa; Takashi Kusaka; Kenichi Isobe; Susumu Itoh; Shoju Onishi
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Paper Abstract

This paper describes the theory and the apparatus on our newly developed 64 channel optical imager that enables imaging of three components, indocyanine green (ICG), oxyHb and deoxyHb. Knowledge on blood flow is obtainable using ICG as a blood flow indicator that is to be introduced via injection. ICG has a strong absorption at 805nm, therefore the changes in ICG is detectable with NIR spectroscopy separating from oxyHb and deoxyHb using proper three wavelengths. In addition to the system description, it describes an animal experiment and a phantom test for the validation study. It discusses independence features of ICG on Hb values. Using a simple quasi Lambert Beer's law, it proved the excellent separation of the three components. It also discusses the factors that affect the performance of signal separation.

Paper Details

Date Published: 29 June 2001
PDF: 9 pages
Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); doi: 10.1117/12.434516
Show Author Affiliations
Ichiro Oda, Shimadzu Corp. (Japan)
Yukihisa Wada, Shimadzu Corp. (Japan)
Sadao Takeuchi, Shimadzu Corp. (Japan)
Yukio Oikawa, Shimadzu Corp. (Japan)
Naojumi Sakauchi, Shimadzu Corp. (Japan)
Yasunobu Ito, Shimadzu Corp. (Japan)
Ikuo Konishi, Shimadzu Corp. (Japan)
Yoshio Tsunazawa, Shimadzu Corp. (Japan)
Takashi Kusaka, Kagawa Medical Univ. (Japan)
Kenichi Isobe, Kagawa Medical Univ. (Japan)
Susumu Itoh, Kagawa Medical Univ. (Japan)
Shoju Onishi, Kagawa Medical Univ. (Japan)

Published in SPIE Proceedings Vol. 4250:
Optical Tomography and Spectroscopy of Tissue IV
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva Marie Sevick-Muraca, Editor(s)

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